Most of us think of inflammation as the red tenderness that appears on the surface of a scraped knee or burnt finger. But it’s much more than skin deep. Inflammation occurs throughout the body, as part of our immune response, helping us to defeat bacterial infections and destroy tumours.

When it’s a short-term response, inflammation is essential – without it, even a paper cut could be fatal. But when it becomes chronic, it can wreak havoc.

“Chronic inflammation means your body is always mounting an inflammatory response,” says researcher Dr Roslyn Kemp from the University of Otago in Dunedin, New Zealand. “It can become a perpetuating problem and result in tissue damage, which triggers a whole new round of inflammation.”

Scientists are now realising chronic inflammation is an unsuspected component of a number of diseases. “There are not 20 different things going wrong to give 20 different disease states,” says Associate Professor Lindsay Brown, of the School of Biomedical Sciences at The University of Queensland, Australia. “An underlying mechanism causing damage to individual cells is coming forward as the way disease starts.”

I can’t feel it, so why the fuss?

If you cut yourself, your immune system triggers a chain of events to limit the damage. This is known as acute (short-term) inflammation. First, blood flow increases at the injury site, providing white blood cells that can neutralise any bacteria present and prevent infection. Other proteins arrive to seal off the area, preventing germs spreading. “Accumulation of cells and fluids from the bloodstream cause swelling, heat and pain in the tissue,” says Kemp. These symptoms are your body’s way of telling you to slow down. It’s a nifty system. “Inflammation has evolved to fight infection – it’s very effective at getting an immediate and appropriate immune response to the site of infection,” she says.

But the type of inflammation causing a stir among scientists and doctors is more complex than this. You can’t see or feel chronic (long-term), systemic inflammation the way you can a scraped knee. Undetected or not, inflammation that overstays its welcome is dangerous. “In most cases, when it starts causing problems, the inflammation is simply being maintained. It hasn’t been turned off when it should have been,” says Brown.

You may not see or feel this chronic inflammation, but it leaves a trail of markers, including something called C-reactive protein (CRP), which shows up in a simple blood test.

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3 of 4 Comments

RD Editor on 14 October 2011 ,04:05

Unfortunately, we don't have specific information about inflammation of the hip on our website – we’d recommend consulting a doctor. Good luck, RD Editor

E.Felicia Neethling on 05 October 2011 ,05:14

Thanks for this article! I would like to know more about inflammation of the hip that is very pynfull. Please and thank you!

RD Editor on 13 September 2011 ,08:31

Part of the article was missing, but we've now fixed it. Thanks for letting us know! - RD Editor

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